12f. Agitation - Is the participant easily distressed or angered, or hard to handle, or uncooperative, or resistive to care or to help from others?
12i. Psychosis - Auditory hallucinations
12c. Anxiety - Does the participant seem very nervous, worried, or frightened for no apparent reason? Do they seem very tense or fidgety? Do they seem afraid to be apart from caregivers or from others that they trust?
12a. Apathy/withdrawal - Has the participant lost interest in the world around them, lost interest in doing things, or lack motivation for starting new activities?
12b. Depressed mood - Does the participant seem sad or depressed, or say that they feel sad or depressed?
12m. Disinhibition - Does the participant act impulsively without thinking, say things that are not usually done or said in public, or do things that are embarrassing to caregivers or others, or do they talk personally to strangers or have disregard for personal hygiene?
12e. Irritability - Does the participant get irritated and easily disturbed? Are their moods very interchangeable? Are they abnormally impatient?
12u. Participant currently manifests meaningful change in behavior? Other:
12n. Personality change - Does the participant exhibit bizarre behavior or behavior uncharacteristic of the participant, such as unusual collecting, suspiciousness (without delusions), unusual dress, or unusual eating behaviors?
12t. REM sleep behavior disorder - While sleeping, does the participant appear to
repeatedly act out their dreams (e.g., punch or flail their arms, shout, or scream)?
12h. Psychosis - Visual hallucinations
12h2. IF YES, do their hallucinations include well formed and detailed images of objects or people, either as independent images or as part of other objects?
9f. Attention/concentration - Does the participant have a short attention span or limited ability to concentrate? Are they easily distracted?
9g. Fluctuating cognition - Does the participant exhibit pronounced variation in attention and alertness, noticeably over hours or days-for example, long lapses or periods of staring into space, or times when their ideas have a disorganized flow?
9c. Executive function (judgment, planning, and problem-solving) - Does the participant have trouble planning complex activities like trips, financial transactions, parties, or group meetings?
9d. Language - Does the participant have hesitant speech, have trouble finding words, use inappropriate words without self-correction, or have trouble with speech comprehension?
9a. Memory - Does the participant forget conversations or dates, repeat questions or
statements, or misplace things more than usual?
10. Mode of onset of cognitive symptoms
Indicate the mode of onset for the most prominent cognitive problem that is causing the participant's complaints and/or affecting the participant's function.
9b. Orientation - Does the participant have trouble knowing the day, month, and year, forget names of people they know well, get lost in familiar locations, or not recognize familiar locations?
9h. Indicate whether the participant currently is meaningfully impaired in other cognitive domains
9e. Visuospatial function - Does the participant have difficulty interpreting visual stimuli or finding their way around in familiar environments?
19. Overall course of decline of cognitive/behavioral/motor syndrome:
11. Based on the clinician's judgment, does the participant manifest clinically meaningful neuropsychiatric symptoms or meaningful change in behavior?
14. Based on the clinician's judgment, is the participant currently experiencing any meaningful changes in motor function?
20. Indicate the predominant domain that was first recognized as changed in the participant:
15b. Falls - Has the participant had an increase in frequency of falls compared with their stable baseline prior to the current syndrome?
15a. Gait disorder - Has the participant's walking changed, not specifically due to arthritis, injury, or peripheral neuropathy? Are they unsteady, or do they shuffle when walking, have little or no arm-swing, or drag a foot?
18. Were changes in motor function suggestive of amyotrophic lateral sclerosis (ALS) (e.g., changes in muscle strength, or muscle twitches in one or more limbs, or slurred speech)?
16. Mode of onset for motor symptoms: Indicate the mode of onset for the most prominent motor problem that is causing the participant's complaints and/or affecting the participant's function.
17. Were changes in motor function suggestive of parkinsonism?
15c. Slowness - Has the participant noticeably slowed down in walking, moving, or writing by hand, other than due to an injury or illness?
15d. Tremors - Has the participant had rhythmic shaking, especially in the hands, arms, legs, head, mouth, or tongue?
7. Does the participant have any neuropsychiatric/behavioral symptoms, decline in any
cognitive domains, or changes in any motor domains?
12s. If any of the personality-related behavioral changes in 12m-12r are present, at what age did they begin? (The clinician must use their best judgment to estimate an age of onset.)
9i. If any of the cognitive symptoms in 9a-9h are present, at what age did they begin? (The clinician must use their best judgment to estimate an age of onset.)
4. Does the co-participant report a decline in any cognitive domain (relative to stable baseline prior to onset of current syndrome)?
1. Does the participant report a decline in any cognitive domain (relative to stable baseline prior to onset of current syndrome)?